Pharmaceutical form
Solution for injection
A clear, colourless solution, free from visible particles.
Pharmacological properties
Pharmacotherapeutic group: other gynecologicals; prostaglandins.
ATC Vet code: QG02AD90
Pharmacodynamic properties
Cloprostenol, a synthetic prostaglandin analogue, structurally related to Prostaglandin F2α (PGF2α), is a potent luteolytic agent which provokes morphological and functional regression (luteolysis) of the corpus luteum. In pregnant females, maintenance of pregnancy is dependent on progesterone secreted by the corpus luteum. Luteolysis at the end of gestation causes parturition.
Furthermore, this group of substances has a contractile effect on the smooth muscles (uterus, gastro-intestinal tract, respiratory tract, vascular system).
Cloprostenol does not demonstrate any androgenic, oestrogenic or anti progesterone activity and its effect on pregnancy is due to its luteolytic property.
Unlike other prostaglandin analogues, cloprostenol has no thromboxane A2 activity and does not cause platelet aggregation.
Pharmacokinetic particulars
After intramuscular injection, cloprostenol is rapidly absorbed with peaks of concentration usually reached within the first few minutes. The cloprostenol is then eliminated rapidly in less than 2 hours. A slow elimination phase follows with concentrations below quantifiable levels a few hours after administration.
Intramuscular administration of 15-14C-cloprostenol show that cloprostenol is metabolised followed by excretion in approximately equal proportions in urine and faeces. A major portion of the dose is excreted within 0-4 hours and most of the dose is eliminated within 24 hours. The major route of metabolism appears to be β-oxidation to the tetranor or dinor acids of cloprostenol.
Pharmaceutical particulars
List of excipients
Benzyl alcohol (E1519)
Sodium citrate
Citric acid
Sodium chloride
Water for injections
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
The product should not enter water courses as this may be dangerous for fish and other aquatic organisms.